Pharmaceuticals and Cosmetics

Insulin is produced via genetically engineered microorganisms in sterile bioreactors. During formulation, maintaining a homogeneous concentration is critical to avoid dosage inaccuracies, but insulin’s sensitivity to shear makes conventional mixing risky. The FUNDAMIX® Vibro-Mixer provides efficient, low shear agitation that prevents protein denaturation while ensuring consistent distribution. Its membrane sealed design enables sterile operation without mechanical seals and supports full CIP and SIP procedures. Designed for hygienic processes, FUNDAMIX® helps meet the strict purity and safety standards required in insulin production.​

Plasma fractionation is a multi-step process used to isolate valuable therapeutic proteins from mammalian blood. FUNDAMIX® mixers are ideally suited for this application, ensuring precise and homogeneous mixing during the addition of ethanol and octanoic acid, which are critical for selective protein precipitation. Poor mixing can lead to pH inhomogeneity, resulting in reduced purity and yield. With its vertical oscillation and low shear characteristics, FUNDAMIX® promotes fast, even distribution of reagents and stable conditions throughout the batch. This leads to higher process efficiency, better product quality, and improved recovery of proteins such as albumin and immunoglobulins.​

FUNDAMIX® provides an ideal mixing solution for the preparation of sterile media, buffers, and reagents in pharmaceutical and biotech processes. The system’s closed, hygienic design and lack of rotating parts minimize contamination risk and ensure cleanroom compatibility. Its vibration-based mixing promotes uniformity while simplifying CIP and SIP procedures. Consistent and reproducible mixing performance supports compliance with stringent GMP and validation requirements.​

Creating stable oil-in-water or water-in-oil emulsions requires uniform energy distribution and gentle but effective agitation. FUNDAMIX® delivers efficient mixing through vertical oscillation, enabling the formation of fine, stable droplets without introducing shear-related damage. This makes it well suited for pharmaceutical, cosmetic, and nutraceutical emulsions where consistency, appearance, and product stability are critical.​

​In extraction processes, efficient contact between solids and liquid solvents is essential to maximize yield and reduce processing time. FUNDAMIX® enhances mass transfer through uniform mixing and minimal dead zones. The gentle motion prevents solids from settling while avoiding excessive shear that could degrade sensitive compounds. Applications include herbal extracts, active pharmaceutical ingredients, and nutraceuticals.​

​Homeopathic production often involves multiple serial dilutions and succussion steps, where uniform and reproducible agitation is essential. FUNDAMIX® offers gentle, vibration-based mixing that supports the activation process while preserving the integrity of the highly diluted solutions. The system’s hygienic design and ease of validation make it well suited for regulated production environments.​

Producing stable emulsions for creams, lotions, and other cosmetics requires effective mixing of immiscible phases without compromising ingredient integrity. FUNDAMIX® enables cold emulsification while maintaining uniform droplet size and smooth product texture. Its vibration-based technology handles high-viscosity formulations with ease and operates in a hygienic, enclosed environment. Compared to rotor-stator systems, it delivers similar results with significantly lower energy consumption, making it a reliable and efficient choice for cosmetic manufacturing.​

DrM’s FUNDAMIX® Vibro-Mixer is an ideal solution for mixing in vaccine manufacturing processes, including the preparation of tetanus vaccines. In anaerobic fermentations, such as those used for tetanus, toxic gases like hydrogen and carbon dioxide can hinder cell growth if not effectively removed. The FUNDAMIX® system provides efficient gas removal through gentle vertical liquid movement, minimizing shear stress on sensitive cell structures. Its vortex-free mixing ensures a homogenous environment while preserving cell integrity. The system is fully compatible with CIP and SIP procedures and complies with cGMP and EHEDG hygienic design standards.​