How can low-shear mixing support reliable insulin production at industrial scale?

DrM Group has successfully delivered a turnkey skid-mounted plant featuring FUNDAMIX® mixing technology for a pharmaceutical customer in Pakistan. The system is designed for insulin production, where gentle handling, hygienic design, and process reliability are critical to product quality and operational performance.

What were the process requirements for this insulin production project?

Insulin manufacturing places stringent demands on mixing and process equipment, particularly when handling shear-sensitive proteins. Equipment must ensure homogeneous mixing while minimising mechanical stress, product losses, and contamination risk, all within a fully validated pharmaceutical environment.

For this project, the scope required:

  • Low-shear mixing suitable for sensitive biological products

  • Hygienic design in line with pharmaceutical standards

  • Integrated cleaning and sterilisation capability

  • A compact, skid-mounted concept for efficient installation

How was the FUNDAMIX® turnkey system engineered and delivered?

The project was executed as an international collaboration led by DrM Switzerland, with fabrication and assembly carried out by DrM Shanghai and supported by DrM’s global engineering network. From concept development through detailed engineering and Factory Acceptance Testing (FAT), the teams worked closely with the customer to deliver a fully customised solution.

The turnkey skid-mounted plant includes:

All components were designed and manufactured in accordance with relevant pharmaceutical standards to ensure precision, hygiene, and long-term reliability. The customer was welcomed on site for final inspection and testing prior to shipment.

Why is FUNDAMIX® suited for shear-sensitive insulin production?

FUNDAMIX® technology is specifically designed for applications where conventional rotating mixers may introduce excessive shear. Key advantages in insulin production include:

  • Efficient yet low-shear mixing, suitable for sensitive proteins

  • Low heel volume, reducing product losses

  • Proven performance for shear-sensitive biological systems

These characteristics support consistent product quality while improving process efficiency and yield.

How was the system installed and commissioned on site?

Following delivery, DrM service technicians supported on-site installation and commissioning of the packaged unit. The project progressed from engineering and fabrication through FAT and into the installation and start-up phase at the customer’s facility.

Beyond installation, DrM’s scope includes commissioning support, operator training, maintenance services, and spare parts supply, ensuring reliable operation throughout the system’s service life.

By combining low-shear mixing technology with a fully integrated, skid-mounted design, this project demonstrates how FUNDAMIX® systems can support robust and efficient insulin production in regulated pharmaceutical environments.