A New Era in Single-Use
Filtration
Introducing our FUNDALOOP® filter, the first single-use, multi-cycle filtration system for safe, scalable, and efficient solid-liquid separation.
Designed to Perform Better Cycle After Cycle
FUNDALOOP® combines closed system operation with multi cycle efficiency to deliver reliable, high yield filtration. Its smart design reduces waste, protects product quality, and adapts easily as your process scales.
Self-Cleaning Backflush Keeps Performance High
The FUNDALOOP® regenerates its filter media after every cycle using a patented backflush step, preventing cloth fouling, extending bag life, and reducing plastic waste.
High Flow Rates Without Compromise
Thin filter media combined with filter aids (like diatomaceous earth) maintain low resistance and high flow rates while achieving high filtrate clarity.
Easy Scale-Up Without Changing Equipment
Scale your process from small to commercial volumes using the same FUNDALOOP® system, simply increase the number of cycles to handle larger batch sizes.
Multi-Cycle Filtration
How It Works
Cell culture fluid is pumped into the bag and filtered. Solids form a porous filter cake on the elements, which is covered with the filter cloth, while the clarified liquid passes through.
Once filtration is complete, pressurized gas compresses the bag, pushing remaining liquid (heel volume) through the filter for maximum product recovery. An optional cake wash can be applied.
Sterile liquid (e.g., buffer or WFI) is flushed in reverse through the filter elements. This expels the solids from the filter candles and therefore regenerates the filter cloth.
The discharge valve opens. Solids and residual wash liquids are removed from the bag. The system is now ready for the next filtration cycle.
A Smarter Alternative to Centrifuges & Depth Filters
Traditional harvest and clarification methods rely on centrifuges or multi-stage depth filtration setups, both with well-known challenges: fouling, high waste, low flexibility, and inefficient scalability. The FUNDALOOP® filter replaces these outdated systems with a fully enclosed, single-use solution that’s more efficient in speed, space, and scale-up procedure.
Centrifuge
Depth Filter
FUNDALOOP®
Back-Flush / Regeneration
Multi-cycle Use
Waste Generation
High
High
Low
Scalability
Difficult
Linear but costly
Linear and cost efficient
Flow Rates
Limited
Significantly drops as filter fouls
High & stable as it evades cloth fouling
Turnkey
Modular Design, Scalable Benefits
FUNDALOOP® is available in several standard configurations, each offering process consistency, efficiency, and cleanability. The following sections outline its key features and technical specifications.
Primary and secondary filtration in a single step
High flow rate and filtrate clarity
Sustainable, reduced amount of plastic waste
Turnkey system, no preflush needed
Up to 60% reduced clean room footprint
Fully automated, CFR 21 part 11 compliant software
Less product contact and leachables/extractables
CapEx and OpEx savings
Hardware
FL 50 Skid
FL 200 Skid
FL 3000 Skid
SU consumable
FL 50 skid
FL 200 skid
FL 3000 Skid
Batch size (L)
≤ 100
≤ 400
≤ 5000
Filter area (m²)
0.006
0.018
0.44 / 0.88
Number of elements
1
1
2/4
Dimensions (mm)
-
-
-
Materials of construction
PE, PP, EPDM
PE, PP, EPDM
PE, PP, EPDM
Pressure rating (barg)
3
3
3
Heel volume filtration is an integrated step that allows FUNDALOOP® SU to recover the residual liquid remaining left inside the bag after the main filtration cycle.
How it works:
Pressurized air is introduced into the space between the outer pressure vessel and the inner plastic bag.
The bag is squeezed inward, pressing the remaining liquid through the filter cake and out through the filtrate line.
No pump or spray nozzle is involved, and the amount of pressurized air used can be adjusted to suit each individual application.
The process liquid remains entirely contained within the single-use assembly.
Why it matters:
Improves yield by recovering residual product that would otherwise be lost
Minimizes waste and reduces the amount of liquid discarded
Supports batch integrity within a closed, single-use system
AGC Biologics
"DrM's FUNDALOOP® was able to filter a lysed E.coli culture at a high flow rate and low turbidity, while also achieving an excellent plasmid DNA yield. Unlike depth filters, the FUNDALOOP® did not clog despite the feed being highly non-uniform. We also appreciated the quick and competent customer service"
Test FUNDALOOP®
in Your Process.
From Lab to
Production Scale
Before investing in a full-scale system, DrM offers lab- and pilot-scale FUNDALOOP® units to test performance in real process conditions.
Evaluate filtration efficiency, product recovery, and cycle parameters, using the same multi-cycle technology applied at production scale.
- Available for rental or purchase
- Identical mixing principle as production units
- Easy setup for lab or pilot environments
- Ideal for trials, R&D, and process development
- Supported by DrM’s technical experts
Explore More Single-Use Solutions
DrM also offers single-use mixing systems and valve technology designed to work seamlessly across upstream and downstream processes.
Resources & Downloads
Download detailed brochures, product overviews, and technical resources to learn more about FUNDAMIX® SU and DrM’s complete single-use mixing solutions. Everything you need to explore, plan, or specify your system is available here.
