Pre-sterilised and validated filter enclosure options.
Bottom port for cyclically discharge of the washed down cake.
Fully enclosed containment ensures safe handling of hazardous components.
Customizable filtration area.
Wheels provide full unit mobility.
FUNDALOOP® single-use filters offer a superior alternative to traditional disposable filter cartridges for cell harvesting and clarification in pharmaceutical processes. The filtration system features multiple vertically aligned filter elements packed into a fully contained FUNDALOOP® Bag, which is then placed inside a transparent pressure vessel for optimal visibility and performance.
The FUNDALOOP® system can streamline primary and secondary clarification into a single step, due to its ability to regenerate the filter media and minimize cloth fouling over time. It provides a unique intersection between single-use and multi-cycle technologies — an innovative approach that has been previously unexplored in the bioprocessing industry.
Multi-Cycle Operating Principles
Cell culture fluid is pumped into the bag and filtered, creating a porous cake of solids on the elements.
Once maximum pressure or cake thickness is reached, heel-volume filtration is executed by introducing pressurized gas to the area in between the housing vessel and the plastic bag. This squeezes the remaining liquid through the filter elements and out through the filtrate line. Cake washing is an optional step here to ensure that product remaining in the cake can be recovered.
The filter cloth is regenerated by pumping a sterile liquid (such as buffer or WFI) back through the opposite direction of the filter elements to dislodge the cake and other fine particles that may have become embedded in the cloth.
The discharge valve opens and remaining liquids and solids are discharged from the bag as waste. The bag is now clean and ready to start filtration again.
Filtration of catalyst recovery, active carbon treatment, crystal separation, impurities removal or polishing. Cake treatment such as washing, extraction, and drying to increase the yield and reduce contamination of intermediates.
Filtration of fermentation broths, removal of activated carbon from antibiotic solutions, washing and purification of antibiotic crystals.
Filtration of cell debris and active ingredients after fermentation.
Removal of debris from ruptured cells following fermentation
Efficient clarification of E. Coli lysates without clogging.
Catalyst recovery, activated carbon removal, salt filtration and polishing of product solutions.
